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KMID : 0613820210310020149
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Journal of Life Science
2021 Volume.31 No. 2 p.149 ~ p.157
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Antioxidant and Antiproliferating Effects of Prunus mume Vinegar Powder on Breast Cancer Cells
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Park Wool-Lim
Kim Jeong-Ho
Heo Ji-An
Won Yeong-Seon
Seo Kwon-Il
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Abstract
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Prunus mume Sieb. et Zucc is widely distributed in East Asia (Korea, Japan, and China), and its fruit is often used as a medication and food material. However, because most previous studies have only investigated the state of Prunus mume fruit extract, studies on the various ways of processing this extract are still needed to increase its utilization. In this study, we evaluated the physicochemical properties and physiological activities of spray-dried Prunus mume vinegar powder (SPP). The sugar content, pH, total acidity, and moisture content of the SPP were 8.90 °Brix, 3.19, 1.05%, and 3.07%, respectively. The SPP exhibited significantly high antioxidant activity in terms of DPPH radical scavenging activity (65.55%), reducing power (1.48), and hydrogen peroxide scavenging activity (48.07%). In addition, the SPP remarkably decreased the cell viability of human breast MDA-MB-231 and human skin cancer SK-MEL-28 in a dose-dependent manner. The morphological results of the treatment of MDA-MB-231 cells with SPP were distorted, shrunken cell masses. Furthermore, apoptotic bodies and nuclear condensation formed in the SPP-treated MDA-MB-231 cells. The total polyphenol and flavonoid contents of the SPP were 59.58 μg/g (gallic acid equivalent) and 57.56 μg/g (quercetin equivalent). The results of this study indicate that SPP, which has antioxidant activity and anticancer effects, can be useful in the development of natural medicines and functional food ingredients.
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KEYWORD
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Antioxidant, antiproliferation, human breast cancer, spray-dried Prunus mume vinegar powder
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